medullary Thyroid cancer

A neuroendocrine carcinoma that originates in the C-cells of the THYROID GLAND; about 10-20% of cases are familial. It occurs sporadically or is associated with MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES. Germline and somatic mutations in RET and NTRK1 genes have been identified. OMIM: 155240

Also Known As:

Thyroid cancer, medullary; Medullary thyroid cancer (MTC); Thyroid carcinoma, medullary

Neoplasms: 1324753
- Neoplasms by Site: 4
  - Head and Neck Neoplasms: 18117
    - Thyroid Neoplasms: 18040
      - medullary Thyroid cancer: 958
  - Endocrine Gland Neoplasms: 130
    - Thyroid Neoplasms: 18040
      - medullary Thyroid cancer: 958
- Neoplasms by Histologic Type: 2
  - Germ Cell and Embryonal Neoplasms: 4454
    - Neuroectodermal Tumors: 217
      - Neuroendocrine Tumors: 6270
        Neuroendocrine Carcinoma: 1123
        medullary Thyroid cancer: 958
  - Glandular and Epithelial Neoplasms: 439
    - Carcinoma: 141855
      - Adenocarcinoma: 58365
        Neuroendocrine Carcinoma: 1123
        medullary Thyroid cancer: 958
  - Nerve Tissue Neoplasms: 1
    - Neuroectodermal Tumors: 217
      - Neuroendocrine Tumors: 6270
        Neuroendocrine Carcinoma: 1123
        medullary Thyroid cancer: 958
Endocrine System Diseases: 968
- Thyroid Diseases: 6126
  - Thyroid Neoplasms: 18040
    - medullary Thyroid cancer: 958
- Endocrine Gland Neoplasms: 130
  - Thyroid Neoplasms: 18040
    - medullary Thyroid cancer: 958

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Disease

Drug/Important Bio-Agent (IBA)